Peptide Utility (PU) search server: A new tool for peptide sequence search from multiple databases

Tanishq Chamoli; Alisha Khera; Akanksha Sharma; Anshul Gupta; Sonam Garg; Kanishk Mamgain; Aayushi Bansal; Shriya Verma; Ankit Gupta; Hema K. Alajangi; Gurpal Singh; Ravi P. Barnwal

Heliyon (Dec 2022)

Peptide Utility (PU) search server: A new tool for peptide sequence search from multiple databases

Tanishq Chamoli,
Alisha Khera,
Akanksha Sharma,
Anshul Gupta,
Sonam Garg,
Kanishk Mamgain,
Aayushi Bansal,
Shriya Verma,
Ankit Gupta,
Hema K. Alajangi,
Gurpal Singh,
Ravi P. Barnwal

Affiliations

Tanishq Chamoli: Department of Computer Science and Engineering, Chandigarh College of Engineering and Technology, Chandigarh, India
Alisha Khera: Department of Biophysics, Panjab University, Chandigarh 160014, India; National Centre for Cell Science, NCCS Complex, S. P. Pune University Campus, Ganeshkhind, Pune, Maharashtra 411007, India
Akanksha Sharma: Department of Biophysics, Panjab University, Chandigarh 160014, India; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
Anshul Gupta: Department of Computer Science and Engineering, Chandigarh College of Engineering and Technology, Chandigarh, India
Sonam Garg: Department of Computer Science and Engineering, Chandigarh College of Engineering and Technology, Chandigarh, India
Kanishk Mamgain: Department of Computer Science and Engineering, Chandigarh College of Engineering and Technology, Chandigarh, India
Aayushi Bansal: Department of Computer Science and Engineering, Chandigarh College of Engineering and Technology, Chandigarh, India
Shriya Verma: Department of Computer Science and Engineering, Chandigarh College of Engineering and Technology, Chandigarh, India
Ankit Gupta: Department of Computer Science and Engineering, Chandigarh College of Engineering and Technology, Chandigarh, India
Hema K. Alajangi: Department of Biophysics, Panjab University, Chandigarh 160014, India; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India; Corresponding author.
Gurpal Singh: University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India; Corresponding author.
Ravi P. Barnwal: Department of Computer Science and Engineering, Chandigarh College of Engineering and Technology, Chandigarh, India; Corresponding author.

Journal volume & issue: Vol. 8, no. 12
p. e12283

Abstract

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Proteins are essential building blocks in humans that have garnered huge attention from researchers worldwide due to their numerous therapeutic applications. To date, different computational tools have been developed to extract pre-existing information on these biological molecules, but most of these tools suffer from limitations such as non-user friendly interface, redundancy of data, etc. To overcome these limitations, a user-friendly interface, the Peptide Utility (PU) webserver (https://chain-searching.herokuapp.com/) has been developed for searching and analyzing homologous and identical protein/peptide sequences that can be searched from approximately 0.4 million sequences (structural and sequence information) in both online and offline modes. The PU web server can also be used to study different types of interactions in PDBSum, identifying the most dominating interface residues, the most prevalent interactions, and the interaction preferences of different residues. The webserver would also pave way for the design of novel therapeutic peptides and folds by identifying conserved residues in the three-dimensional structure space of proteins.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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