Nature Communications (Nov 2022)
H7N9 avian influenza virus infection in men is associated with testosterone depletion
- Tian Bai,
- Yongkun Chen,
- Sebastian Beck,
- Stephanie Stanelle-Bertram,
- Nancy Kouassi Mounogou,
- Tao Chen,
- Jie Dong,
- Bettina Schneider,
- Tingting Jia,
- Jing Yang,
- Lijie Wang,
- Andreas Meinhardt,
- Antonia Zapf,
- Lothar Kreienbrock,
- Dayan Wang,
- Yuelong Shu,
- Gülsah Gabriel
Affiliations
- Tian Bai
- Viral Zoonoses-One Health, Leibniz Institute for Virology (LIV)
- Yongkun Chen
- School of Public Health (Shenzhen), Sun Yat-sen University
- Sebastian Beck
- Viral Zoonoses-One Health, Leibniz Institute for Virology (LIV)
- Stephanie Stanelle-Bertram
- Viral Zoonoses-One Health, Leibniz Institute for Virology (LIV)
- Nancy Kouassi Mounogou
- Viral Zoonoses-One Health, Leibniz Institute for Virology (LIV)
- Tao Chen
- Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Jie Dong
- Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Bettina Schneider
- Department of Biometry, Epidemiology and Information Processing, University of Veterinary Medicine Hannover
- Tingting Jia
- School of Public Health (Shenzhen), Sun Yat-sen University
- Jing Yang
- Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Lijie Wang
- Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Andreas Meinhardt
- Institute for Anatomy and Cell Biology, Justus-Liebig University of Gießen
- Antonia Zapf
- Institute for Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf
- Lothar Kreienbrock
- Department of Biometry, Epidemiology and Information Processing, University of Veterinary Medicine Hannover
- Dayan Wang
- Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Yuelong Shu
- Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Gülsah Gabriel
- Viral Zoonoses-One Health, Leibniz Institute for Virology (LIV)
- DOI
- https://doi.org/10.1038/s41467-022-34500-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Very little is known about biological sex differences in influenza disease outcome. In 2013, avian influenza (H7N9) infections in humans have been reported with higher frequency in men than women. Here, Bai et al. report that low testosterone levels in men correlate with poor infection outcome. They confirm the causal link between viral infection and testosterone depletion using a mouse model.
