Noncoding Regulatory Mutations as a Driving Event for the Oncogenic Core Regulatory Circuitries of Neuroblastoma

Vincenzo Aievola; Vito Alessandro Lasorsa; Annalaura Montella; Ferdinando Bonfiglio; Marianna Avitabile; Teresa Maiorino; Matilde Tirelli; Giuseppe D’Alterio; Matthias Fischer; Frank Westermann; Achille Iolascon; Mario Capasso

doi:10.3390/proceedings2024100018

Proceedings (Mar 2024)

Noncoding Regulatory Mutations as a Driving Event for the Oncogenic Core Regulatory Circuitries of Neuroblastoma

Vincenzo Aievola,
Vito Alessandro Lasorsa,
Annalaura Montella,
Ferdinando Bonfiglio,
Marianna Avitabile,
Teresa Maiorino,
Matilde Tirelli,
Giuseppe D’Alterio,
Matthias Fischer,
Frank Westermann,
Achille Iolascon,
Mario Capasso

Affiliations

Vincenzo Aievola: Department of Electrical Engineering and Information Technologies, University of Naples Federico II, Naples 80125, Italy
Vito Alessandro Lasorsa: CEINGE Biotecnologie Avanzate Franco Salvatore s.c.ar.l., Naples 80131, Italy
Annalaura Montella: Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy
Ferdinando Bonfiglio: Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy
Marianna Avitabile: Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy
Teresa Maiorino: Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy
Matilde Tirelli: European School of Molecular Medicine, University of Milan, Milan 20139, Italy
Giuseppe D’Alterio: European School of Molecular Medicine, University of Milan, Milan 20139, Italy
Matthias Fischer: Experimental Pediatric Oncology, Children’s Hospital and Center for Molecular Medicine, Medical Faculty, University of Cologne, Cologne 50937, Germany
Frank Westermann: Hopp-Children’s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg 69120, Germany
Achille Iolascon: Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy
Mario Capasso: Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy

DOI: https://doi.org/10.3390/proceedings2024100018
Journal volume & issue: Vol. 100, no. 1
p. 18

Abstract

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Neuroblastoma (NB) is a pediatric tumor composed of adrenergic (ADRN) and mesenchymal-like (MES) cells which derive from the dysregulation of normal cell differentiation imposed by NB Core Regulatory Circuitries (CRCs) [...]

Published in Proceedings

ISSN: 2504-3900 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: General Works
Website: http://www.mdpi.com/journal/proceedings

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Abstract

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