Scientific Reports (Oct 2021)

Chagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes

  • Israel Molina,
  • Milena Soriano Marcolino,
  • Magda Carvalho Pires,
  • Lucas Emanuel Ferreira Ramos,
  • Rafael Tavares Silva,
  • Milton Henriques Guimarães-Júnior,
  • Isaias José Ramos de Oliveira,
  • Rafael Lima Rodrigues de Carvalho,
  • Aline Gabrielle Sousa Nunes,
  • Ana Lara Rodrigues Monteiro de Barros,
  • Ana Luiza Bahia Alves Scotton,
  • Angélica Aparecida Coelho Madureira,
  • Bárbara Lopes Farace,
  • Cíntia Alcantara de Carvalho,
  • Fernanda d’Athayde Rodrigues,
  • Fernando Anschau,
  • Fernando Antonio Botoni,
  • Guilherme Fagundes Nascimento,
  • Helena Duani,
  • Henrique Cerqueira Guimarães,
  • Joice Coutinho de Alvarenga,
  • Leila Beltrami Moreira,
  • Liege Barella Zandoná,
  • Luana Fonseca de Almeida,
  • Luana Martins Oliveira,
  • Luciane Kopittke,
  • Luís César de Castro,
  • Luisa Elem Almeida Santos,
  • Máderson Alvares de Souza Cabral,
  • Maria Angélica Pires Ferreira,
  • Natália da Cunha Severino Sampaio,
  • Neimy Ramos de Oliveira,
  • Pedro Ledic Assaf,
  • Sofia Jarjour Tavares Starling Lopes,
  • Tatiani Oliveira Fereguetti,
  • Veridiana Baldon dos Santos,
  • Victor Eliel Bastos de Carvalho,
  • Yuri Carlotto Ramires,
  • Antonio Luiz Pinho Ribeiro,
  • Freddy Antonio Brito Moscoso,
  • Rogério Moura,
  • Carísi Anne Polanczyk,
  • Maria do Carmo Pereira Nunes

DOI
https://doi.org/10.1038/s41598-021-96825-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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Abstract Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecutive patients with confirmed COVID-19 were included from March to September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus and hospital was performed in a 4:1 ratio. Of the 7018 patients who had confirmed COVID-19, 31 patients with CD and 124 matched controls were included (median age 72 (64–80) years-old, 44.5% were male). At baseline, heart failure (25.8% vs. 9.7%) and atrial fibrillation (29.0% vs. 5.6%) were more frequent in CD patients than in the controls (p < 0.05). C-reactive protein levels were lower in CD patients compared with the controls (55.5 [35.7, 85.0] vs. 94.3 [50.7, 167.5] mg/dL). In-hospital management, outcomes and complications were similar between the groups. In this large Brazilian COVID-19 Registry, CD patients had a higher prevalence of atrial fibrillation and chronic heart failure compared with non-CD controls, with no differences in-hospital outcomes. The lower C-reactive protein levels in CD patients require further investigation.