Nature Communications (Nov 2017)
Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models
- Yuichiro Mita,
- Kaho Nakayama,
- Shogo Inari,
- Yukina Nishito,
- Yuya Yoshioka,
- Naoko Sakai,
- Kanade Sotani,
- Takahiro Nagamura,
- Yuki Kuzuhara,
- Kumi Inagaki,
- Miki Iwasaki,
- Hirofumi Misu,
- Masaya Ikegawa,
- Toshinari Takamura,
- Noriko Noguchi,
- Yoshiro Saito
Affiliations
- Yuichiro Mita
- Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences,, Doshisha University
- Kaho Nakayama
- Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences,, Doshisha University
- Shogo Inari
- Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences,, Doshisha University
- Yukina Nishito
- Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences,, Doshisha University
- Yuya Yoshioka
- Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences,, Doshisha University
- Naoko Sakai
- Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences,, Doshisha University
- Kanade Sotani
- Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences,, Doshisha University
- Takahiro Nagamura
- Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences,, Doshisha University
- Yuki Kuzuhara
- Genomics, Proteomics and Biomedical Functions, Department of Life and Medical Systems, Faculty of Life and Medical Sciences,, Doshisha University,
- Kumi Inagaki
- Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences,, Doshisha University
- Miki Iwasaki
- Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences,, Doshisha University
- Hirofumi Misu
- Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences
- Masaya Ikegawa
- Genomics, Proteomics and Biomedical Functions, Department of Life and Medical Systems, Faculty of Life and Medical Sciences,, Doshisha University,
- Toshinari Takamura
- Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences
- Noriko Noguchi
- Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences,, Doshisha University
- Yoshiro Saito
- Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences,, Doshisha University
- DOI
- https://doi.org/10.1038/s41467-017-01863-z
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Selenoprotein P is secreted by the liver and when present in excess it promotes development of type 2 diabetes. Here the authors develop neutralizing antibodies to target human and mouse selenoprotein P, and show that they improve insulin secretion and glucose tolerance in mouse models.
