Long non-coding RNA DARS-AS1 promotes tumor progression by directly suppressing PACT-mediated cellular stress

Liuqing Yang; Kequan Lin; Lin Zhu; Huili Wang; Shuaishuai Teng; Lijun Huang; Shiyi Zhou; Guanbin Zhang; Zhi John Lu; Dong Wang

doi:10.1038/s42003-022-03778-y

Communications Biology (Aug 2022)

Long non-coding RNA DARS-AS1 promotes tumor progression by directly suppressing PACT-mediated cellular stress

Liuqing Yang,
Kequan Lin,
Lin Zhu,
Huili Wang,
Shuaishuai Teng,
Lijun Huang,
Shiyi Zhou,
Guanbin Zhang,
Zhi John Lu,
Dong Wang

Affiliations

Liuqing Yang: School of Life Science, Tsinghua University
Kequan Lin: High Performance Computing Department, National Supercomputing Center in Shenzhen
Lin Zhu: School of Life Science, Tsinghua University
Huili Wang: School of Medicine, Tsinghua University
Shuaishuai Teng: School of Medicine, Tsinghua University
Lijun Huang: State Key Laboratory of Southwestern Chinese Medicine Resources, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine
Shiyi Zhou: State Key Laboratory of Southwestern Chinese Medicine Resources, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine
Guanbin Zhang: Mianyang People’s Hospital
Zhi John Lu: School of Life Science, Tsinghua University
Dong Wang: State Key Laboratory of Southwestern Chinese Medicine Resources, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine

DOI: https://doi.org/10.1038/s42003-022-03778-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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A loss-of-function screen reveals a role for lncRNA DARS-AS1 in promoting cancer cell proliferation and further experiments shows DARS-AS1 regulates the PACT-PKR pathway, overall suggesting it as a potential target for cancer therapy and prognosis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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