npj Genomic Medicine (Aug 2017)
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations
- Sigurgeir Olafsson,
- Pernilla Stridh,
- Steffan Daniël Bos,
- Andres Ingason,
- Jack Euesden,
- Patrick Sulem,
- Gudmar Thorleifsson,
- Omar Gustafsson,
- Ari Johannesson,
- Arni J. Geirsson,
- Arni V. Thorsson,
- Bardur Sigurgeirsson,
- Bjorn Runar Ludviksson,
- Elias Olafsson,
- Helga Kristjansdottir,
- Jon G. Jonasson,
- Jon Hjaltalin Olafsson,
- Kjartan B. Orvar,
- Rafn Benediktsson,
- Ragnar Bjarnason,
- Sjofn Kristjansdottir,
- Thorarinn Gislason,
- Trausti Valdimarsson,
- Evgenia Mikaelsdottir,
- Snaevar Sigurdsson,
- Stefan Jonsson,
- Thorunn Rafnar,
- Dag Aarsland,
- Srdjan Djurovic,
- Tormod Fladby,
- Gun Peggy Knudsen,
- Elisabeth G. Celius,
- Kjell-Morten Myhr,
- Gerdur Grondal,
- Kristjan Steinsson,
- Helgi Valdimarsson,
- Sigurdur Bjornsson,
- Unnur S. Bjornsdottir,
- Einar S Bjornsson,
- Bjorn Nilsson,
- Ole A. Andreassen,
- Lars Alfredsson,
- Jan Hillert,
- Ingrid Skelton Kockum,
- Gisli Masson,
- Unnur Thorsteinsdottir,
- Daniel F. Gudbjartsson,
- Hreinn Stefansson,
- Haukur Hjaltason,
- Hanne F. Harbo,
- Tomas Olsson,
- Ingileif Jonsdottir,
- Kari Stefansson
Affiliations
- Sigurgeir Olafsson
- deCODE genetics/Amgen
- Pernilla Stridh
- Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine
- Steffan Daniël Bos
- Institute of Clinical Medicine, University of Oslo
- Andres Ingason
- deCODE genetics/Amgen
- Jack Euesden
- deCODE genetics/Amgen
- Patrick Sulem
- deCODE genetics/Amgen
- Gudmar Thorleifsson
- deCODE genetics/Amgen
- Omar Gustafsson
- deCODE genetics/Amgen
- Ari Johannesson
- Department of Medicine, Landspitali, the National University Hospital of Iceland
- Arni J. Geirsson
- Department of Medicine, Landspitali, the National University Hospital of Iceland
- Arni V. Thorsson
- Children’s Medical Center, Landspitali, the National University Hospital of Iceland
- Bardur Sigurgeirsson
- Department of Dermatology, Faculty of Medicine, School of Health Sciences, University of Iceland
- Bjorn Runar Ludviksson
- Department of Immunology, Landspitali, the National University Hospital of Iceland
- Elias Olafsson
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Helga Kristjansdottir
- Center for Rheumatology Research, Landspitali, the National University Hospital of Iceland
- Jon G. Jonasson
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Jon Hjaltalin Olafsson
- Department of Dermatology, Faculty of Medicine, School of Health Sciences, University of Iceland
- Kjartan B. Orvar
- The Medical Center
- Rafn Benediktsson
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Ragnar Bjarnason
- Children’s Medical Center, Landspitali, the National University Hospital of Iceland
- Sjofn Kristjansdottir
- The Medical Center
- Thorarinn Gislason
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Trausti Valdimarsson
- The Medical Center
- Evgenia Mikaelsdottir
- deCODE genetics/Amgen
- Snaevar Sigurdsson
- deCODE genetics/Amgen
- Stefan Jonsson
- deCODE genetics/Amgen
- Thorunn Rafnar
- deCODE genetics/Amgen
- Dag Aarsland
- Department of Old Age Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King’s College London
- Srdjan Djurovic
- Department of Medical Genetics, Oslo University Hospital
- Tormod Fladby
- Department of Neurology, Akershus University Hospital
- Gun Peggy Knudsen
- Norwegian Institute of Public Health
- Elisabeth G. Celius
- Department of Neurology, Oslo University Hospital Ullevål
- Kjell-Morten Myhr
- Department of Clinical Medicine, University of Bergen
- Gerdur Grondal
- Center for Rheumatology Research, Landspitali, the National University Hospital of Iceland
- Kristjan Steinsson
- Center for Rheumatology Research, Landspitali, the National University Hospital of Iceland
- Helgi Valdimarsson
- Department of Immunology, Landspitali, the National University Hospital of Iceland
- Sigurdur Bjornsson
- Department of Medicine, Landspitali, the National University Hospital of Iceland
- Unnur S. Bjornsdottir
- Department of Medicine, Landspitali, the National University Hospital of Iceland
- Einar S Bjornsson
- Department of Medicine, Landspitali, the National University Hospital of Iceland
- Bjorn Nilsson
- Department of Laboratory Medicine, Hematology and Transfusion Medicine, BMC
- Ole A. Andreassen
- Division of Mental Health and Addiction, NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital
- Lars Alfredsson
- Institute of Environmental Medicine, Karolinska Institutet
- Jan Hillert
- Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine
- Ingrid Skelton Kockum
- Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine
- Gisli Masson
- deCODE genetics/Amgen
- Unnur Thorsteinsdottir
- deCODE genetics/Amgen
- Daniel F. Gudbjartsson
- deCODE genetics/Amgen
- Hreinn Stefansson
- deCODE genetics/Amgen
- Haukur Hjaltason
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Hanne F. Harbo
- Institute of Clinical Medicine, University of Oslo
- Tomas Olsson
- Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine
- Ingileif Jonsdottir
- deCODE genetics/Amgen
- Kari Stefansson
- deCODE genetics/Amgen
- DOI
- https://doi.org/10.1038/s41525-017-0027-2
- Journal volume & issue
-
Vol. 2,
no. 1
pp. 1 – 12
Abstract
Multiple sclerosis: Sequence variants discovered by meta-analysis informed by genetic correlation Combining studies and comparing across diseases turned up 14 novel gene variants linked to multiple sclerosis (MS). A team led by Kári Stefánsson and Ingileif Jónsdóttir from deCODE genetics in Reykjavík, Iceland, amalgamated data from a large international study of MS with three smaller ones from Sweden, Norway and Iceland. They conducted a meta-analysis on the combined data set — which encompassed around 21,000 MS patients and 372,000 population controls — and uncovered seven new genetic risk variants linked to MS. The researchers then compared the genetic overlap between various autoimmune diseases in the Icelandic cohort, and documented a close relationship between MS and primary biliary cirrhosis (PBC). They looked more closely at variants linked to PBC, and found that seven also increased the risk for MS, bringing the tally of novel gene variants up to fourteen.
