Association of KCNJ11 (rs5219) gene polymorphism with susceptibility to gestational diabetes mellitus: a review and meta-analysis

Abstract

Introduction: Changes in the activity of the gene encoding internal rectifier potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11), due to some polymorphisms of this gene have far-reaching effects on the metabolic processes of people with gestational diabetes mellitus (GDM). This systematic review and meta-analysis were conducted with aim to further evaluate the association between the KCNJ11 (rs5219) polymorphism and GDM. Methods: In this systematic review and meta-analysis, a literature search was performed to identify the relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and some Persian-language databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association between KCNJ11 (rs5219) polymorphisms and susceptibility to GDM in four genetic models. Results: A total of 5578 participants from six articles were included in the meta-analysis. A significant relationship was identified between the KCNJ11 (rs5219) gene polymorphism and GDM in the study population through an additive genetic model (OR = 1.14; 95%CI: 1.00–1.30; P = 0.049) and a recessive genetic model (OR = 0.86; 95% CI: 0.75–0.98; P = 0.033). On the contrary, there was no significant association between the KCNJ11 (rs5219) gene polymorphism and GDM in an allelic genetic model (OR = 1.25; 95%CI: 0.93–1.69; P = 0.136) and the dominant genetic model (OR = 1.15; 95% CI: 0.94–1.41; P = 0.157). Conclusion: The KCNJ11 gene polymorphism (rs5219) is associated with susceptibility to GDM in women. However, more studies on different ethnicities are required to confirm our results.

Keywords

• gestational diabetes mellitus
• kcnj11
• meta-analysis
• polymorphism kcnj11 (rs5219)