Acta Cirúrgica Brasileira (May 2019)

Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats

  • Hüseyin Eken,
  • Orhan Cimen,
  • Ferda Keskin Cimen,
  • Eray Kurnaz,
  • Murat Yildirim,
  • Volkan Tasova,
  • Nezahat Kurt,
  • Kamil Pehlivanoglu,
  • Didem Onk,
  • Asli Ozbek Bilgin

DOI
https://doi.org/10.1590/s0102-865020190040000004
Journal volume & issue
Vol. 34, no. 4

Abstract

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Abstract Purpose: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. Methods: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours. Results: Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group. Conclusion: The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.

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