Genome-wide DNA methylation patterns reveal clinically relevant predictive and prognostic subtypes in human osteosarcoma

Christopher E. Lietz; Erik T. Newman; Andrew D. Kelly; David H. Xiang; Ziying Zhang; Caroline A. Luscko; Santiago A. Lozano-Calderon; David H. Ebb; Kevin A. Raskin; Gregory M. Cote; Edwin Choy; G. Petur Nielsen; Benjamin Haibe-Kains; Martin J. Aryee; Dimitrios Spentzos

doi:10.1038/s42003-022-03117-1

Communications Biology (Mar 2022)

Genome-wide DNA methylation patterns reveal clinically relevant predictive and prognostic subtypes in human osteosarcoma

Christopher E. Lietz,
Erik T. Newman,
Andrew D. Kelly,
David H. Xiang,
Ziying Zhang,
Caroline A. Luscko,
Santiago A. Lozano-Calderon,
David H. Ebb,
Kevin A. Raskin,
Gregory M. Cote,
Edwin Choy,
G. Petur Nielsen,
Benjamin Haibe-Kains,
Martin J. Aryee,
Dimitrios Spentzos

Affiliations

Christopher E. Lietz: Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School
Erik T. Newman: Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School
Andrew D. Kelly: Foundation Medicine
David H. Xiang: Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School
Ziying Zhang: Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School
Caroline A. Luscko: Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School
Santiago A. Lozano-Calderon: Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School
David H. Ebb: Division of Pediatric Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School
Kevin A. Raskin: Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School
Gregory M. Cote: Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School
Edwin Choy: Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School
G. Petur Nielsen: Department of Pathology, Massachusetts General Hospital, Harvard Medical School
Benjamin Haibe-Kains: Department of Medical Biophysics, Princess Margaret Cancer Centre, University of Toronto
Martin J. Aryee: Department of Pathology, Massachusetts General Hospital, Harvard Medical School
Dimitrios Spentzos: Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School

DOI: https://doi.org/10.1038/s42003-022-03117-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 20

Abstract

Read online

Christopher Lietz et al. examined genome-wide methylation in patient cohorts of primary osteosarcoma. Their results suggest that genomic hypomethylation is predictive of response to standard chemotherapy, and provide further insight into clinical implications of methylation patterns.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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