Biogeography of the Relationship between the Child Gut Microbiome and Innate Immune System

Nelly Amenyogbe; Pedro Dimitriu; Kinga K. Smolen; Eric M. Brown; Casey P. Shannon; Scott J. Tebbutt; Phillip J. Cooper; Arnaud Marchant; Tessa Goetghebuer; Monika Esser; Brett B. Finlay; Tobias R. Kollmann; William W. Mohn

doi:10.1128/mBio.03079-20

mBio (Feb 2021)

Biogeography of the Relationship between the Child Gut Microbiome and Innate Immune System

Nelly Amenyogbe,
Pedro Dimitriu,
Kinga K. Smolen,
Eric M. Brown,
Casey P. Shannon,
Scott J. Tebbutt,
Phillip J. Cooper,
Arnaud Marchant,
Tessa Goetghebuer,
Monika Esser,
Brett B. Finlay,
Tobias R. Kollmann,
William W. Mohn

Affiliations

Nelly Amenyogbe: Department of Experimental Medicine, University of British Columbia, Vancouver, Canada
Pedro Dimitriu: Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, Canada
Kinga K. Smolen: Department of Experimental Medicine, University of British Columbia, Vancouver, Canada
Eric M. Brown: Michael Smith Laboratories, University of British Columbia, Vancouver, Canada
Casey P. Shannon: PROOF Centre of Excellence, St. Pauls’s Hospital, University of British Columbia, Vancouver, Canada
Scott J. Tebbutt: PROOF Centre of Excellence, St. Pauls’s Hospital, University of British Columbia, Vancouver, Canada
Phillip J. Cooper: Facultad de Ciencias Medicas, de la Salud y la Vida, Universidad Internacional del Ecuador, Quito, Ecuador
Arnaud Marchant: Institut d’Immunologie Médicale, Université Libre de Bruxelles, Charleroi, Belgium
Tessa Goetghebuer: Département de Pédiatrie, Centre Hospitalier Universitaire St Pierre, Université Libre de Bruxelles, Brussels, Belgium
Monika Esser: Immunology Unit, Division of Medical Microbiology, Department of Pathology, NHLS and Stellenbosch University, Matieland, Stellenbosch, South Africa
Brett B. Finlay: ORCiD; Michael Smith Laboratories, University of British Columbia, Vancouver, Canada
Tobias R. Kollmann: Telethon Kids Institute, Perth, Australia
William W. Mohn: ORCiD; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, Canada

DOI: https://doi.org/10.1128/mBio.03079-20
Journal volume & issue: Vol. 12, no. 1

Abstract

Read online

Both the gut microbiome and innate immunity are known to differ across biogeographically diverse human populations. The gut microbiome has been shown to directly influence systemic immunity in animal models.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal