Nature Communications (Jan 2017)
Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer
- Thomas J. Hoffmann,
- Michael N. Passarelli,
- Rebecca E. Graff,
- Nima C. Emami,
- Lori C. Sakoda,
- Eric Jorgenson,
- Laurel A. Habel,
- Jun Shan,
- Dilrini K. Ranatunga,
- Charles P. Quesenberry,
- Chun R. Chao,
- Nirupa R. Ghai,
- David Aaronson,
- Joseph Presti,
- Tobias Nordström,
- Zhaoming Wang,
- Sonja I. Berndt,
- Stephen J. Chanock,
- Jonathan D. Mosley,
- Robert J. Klein,
- Mridu Middha,
- Hans Lilja,
- Olle Melander,
- Mark N. Kvale,
- Pui-Yan Kwok,
- Catherine Schaefer,
- Neil Risch,
- Stephen K. Van Den Eeden,
- John S. Witte
Affiliations
- Thomas J. Hoffmann
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Michael N. Passarelli
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Rebecca E. Graff
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Nima C. Emami
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Lori C. Sakoda
- Division of Research, Kaiser Permanente, Northern California
- Eric Jorgenson
- Division of Research, Kaiser Permanente, Northern California
- Laurel A. Habel
- Division of Research, Kaiser Permanente, Northern California
- Jun Shan
- Division of Research, Kaiser Permanente, Northern California
- Dilrini K. Ranatunga
- Division of Research, Kaiser Permanente, Northern California
- Charles P. Quesenberry
- Division of Research, Kaiser Permanente, Northern California
- Chun R. Chao
- Department of Research and Evaluation, Kaiser Permanente Southern California
- Nirupa R. Ghai
- Department of Research and Evaluation, Kaiser Permanente Southern California
- David Aaronson
- Department of Urology, Kaiser Oakland Medical Center, Northern California
- Joseph Presti
- Department of Urology, Kaiser Oakland Medical Center, Northern California
- Tobias Nordström
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Zhaoming Wang
- Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Sonja I. Berndt
- Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Jonathan D. Mosley
- Department of Medicine, Vanderbilt University
- Robert J. Klein
- Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Mridu Middha
- Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Hans Lilja
- Departments of Laboratory Medicine, Surgery, and Medicine, Memorial Sloan-Kettering Cancer Center
- Olle Melander
- Department of Clinical Sciences, Lund University
- Mark N. Kvale
- Institute for Human Genetics, University of California San Francisco
- Pui-Yan Kwok
- Institute for Human Genetics, University of California San Francisco
- Catherine Schaefer
- Division of Research, Kaiser Permanente, Northern California
- Neil Risch
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Stephen K. Van Den Eeden
- Division of Research, Kaiser Permanente, Northern California
- John S. Witte
- Department of Epidemiology and Biostatistics, University of California San Francisco
- DOI
- https://doi.org/10.1038/ncomms14248
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Prostate-specific antigen is used as a biomarker of prostate cancer, but levels can be affected by other factors not related to cancer. Here, the authors find genes associated with prostate specific antigen levels in healthy men, which could be used to reduce over-diagnosis and over-treatment.
