Individualized dosing guidelines for PEGasparaginase and factors influencing the clearance: a population pharmacokinetic model

• Robin Q.H. Kloos,
• Ron Mathôt,
• Rob Pieters,
• Inge M. van der Sluis

Affiliations

Robin Q.H. Kloos

Department of pediatric oncology and hematology, Sophia Children’s Hospital – Erasmus MC, Rotterdam

Ron Mathôt

Department of Hospital Pharmacy, Amsterdam University Medical Center, University of Amsterdam, Amsterdam

Rob Pieters

Princess Máxima Center for Pediatric Oncology, Utrecht

Inge M. van der Sluis

Department of pediatric oncology and hematology, Sophia Children’s Hospital – Erasmus MC, Rotterdam, the Netherlands; Princess Máxima Center for Pediatric Oncology, Utrecht