Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy

Yu-Chen Wang; Xi Wang; Jiaji Yu; Feiyang Ma; Zhe Li; Yang Zhou; Samuel Zeng; Xiaoya Ma; Yan-Ruide Li; Adam Neal; Jie Huang; Angela To; Nicole Clarke; Sanaz Memarzadeh; Matteo Pellegrini; Lili Yang

doi:10.1038/s41467-021-23164-2

Nature Communications (Jun 2021)

Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy

Yu-Chen Wang,
Xi Wang,
Jiaji Yu,
Feiyang Ma,
Zhe Li,
Yang Zhou,
Samuel Zeng,
Xiaoya Ma,
Yan-Ruide Li,
Adam Neal,
Jie Huang,
Angela To,
Nicole Clarke,
Sanaz Memarzadeh,
Matteo Pellegrini,
Lili Yang

Affiliations

Yu-Chen Wang: Department of Microbiology, Immunology and Molecular Genetics, University of California
Xi Wang: Department of Microbiology, Immunology and Molecular Genetics, University of California
Jiaji Yu: Department of Microbiology, Immunology and Molecular Genetics, University of California
Feiyang Ma: Department of Molecular, Cell and Developmental Biology, and Institute for Genomics and Proteomics, University of California
Zhe Li: Department of Microbiology, Immunology and Molecular Genetics, University of California
Yang Zhou: Department of Microbiology, Immunology and Molecular Genetics, University of California
Samuel Zeng: Department of Microbiology, Immunology and Molecular Genetics, University of California
Xiaoya Ma: Department of Microbiology, Immunology and Molecular Genetics, University of California
Yan-Ruide Li: Department of Microbiology, Immunology and Molecular Genetics, University of California
Adam Neal: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California
Jie Huang: Department of Microbiology, Immunology and Molecular Genetics, University of California
Angela To: Department of Microbiology, Immunology and Molecular Genetics, University of California
Nicole Clarke: Department of Microbiology, Immunology and Molecular Genetics, University of California
Sanaz Memarzadeh: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California
Matteo Pellegrini: Department of Molecular, Cell and Developmental Biology, and Institute for Genomics and Proteomics, University of California
Lili Yang: Department of Microbiology, Immunology and Molecular Genetics, University of California

DOI: https://doi.org/10.1038/s41467-021-23164-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Monoamine oxidase A (MAO-A) is an outer mitochondrial membrane-bound enzyme best known for its function in the brain, but also linked to cancer progression. Here, the authors show that MAO-A is expressed in tumor associated macrophages, promoting their immunosuppressive properties, and that MAO inhibition suppresses tumor growth in preclinical models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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