CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages

Milton Pereira; Panagiotis Tourlomousis; John Wright; Tom P. Monie; Clare E. Bryant

doi:10.1038/ncomms12874

Nature Communications (Sep 2016)

CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages

Milton Pereira,
Panagiotis Tourlomousis,
John Wright,
Tom P. Monie,
Clare E. Bryant

Affiliations

Milton Pereira: Department of Veterinary Medicine, University of Cambridge
Panagiotis Tourlomousis: Department of Veterinary Medicine, University of Cambridge
John Wright: Department of Veterinary Medicine, University of Cambridge
Tom P. Monie: Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory
Clare E. Bryant: Department of Veterinary Medicine, University of Cambridge

DOI: https://doi.org/10.1038/ncomms12874
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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IL-1β is important for control of bacterial infections, but when deregulated can lead to excessive inflammation. The authors show that the adaptor protein CARD9 suppresses levels of IL-1β and is downregulated during S. Typhimuriuminfection, thus facilitating an inflammatory response

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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