Репродуктивная эндокринология (Mar 2024)
Chronic endometritis and endometriosis: what do they have in common?
Abstract
Background. Chronic endometritis and endometriosis are difficult illnesses to diagnose, due to their non-specific manifestations, but at the same time they are quite common and often result in impaired fertility. Both endometritis and endometriosis are chronic inflammatory diseases that could affect the receptivity of the endometrium, precisely it affects the implantation process, as well as it contributes to early pregnancy losses, which makes a challenge for reproductive specialists. In addition, these diseases negatively affect the social and psychological aspects of a modern woman’s life due to the fact that such common symptoms as pelvic pain, dyspareunia, abnormal uterine bleeding exhaust and deprive the woman at her usual activity and lead to a deterioration of her psycho-emotional state, that requires modern approaches in diagnosis and treatment. Objectives of the study: to identify and investigate the relationship between chronic endometritis and endometriosis. Materials and methods. Endometrial samples taken during pipelle biopsy from 105 women were studied, among them 45 patients without endometriosis and 60 with endometriosis. All women were of reproductive age, had not taken oral contraceptives, progestins, or antibiotics in the past 6 months, and had no neoplastic pathology. A pathohistological examination of the obtained material was performed in all cases. Logistic regression analysis was performed on variables such as age, body mass index, parity, presence of uterine fibroids, and endometriosis. Results. Chronic endometritis was confirmed in 86.7% of patients with endometriosis and in 44.4% of women without signs of endometriosis. Considering these data, it can be argued that chronic endometritis is more common among women with endometriosis compared to women without this pathology. It was also established histologically that the frequency of chronic endometritis in adenomyosis is 2.6 times higher than in other pathologies without endometriosis (52 confirmed cases versus 20). Conclusions. The results of this study indicate a strong connection betISSN 2309-4117ween chronic endometritis and endometriosis.
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