Aziridine Ring Opening as Regio- and Stereoselective Access to <i>C</i>-Glycosyl-Aminoethyl Sulfide Derivatives

Abstract

A short synthetic route to stereoselective access to C-glycosyl-aminoethyl sulfide derivatives has been developed through the reaction of tributhyltin derivatives of glycals with aziridinecarboaldehyde and the regioselective ring opening of a chiral aziridine with thiophenol. The absolute configurations of the resulting diastereoisomers were determined by 1H NMR spectroscopy.

Keywords

• glycals
• aziridine
• sulfides