Ukrainian Neurosurgical Journal (Dec 2009)

Glutathione transferases polymorphism in human brain gliomas and their value for prognosis of chemotherapy efficiency

  • I. G. Vasilyeva,
  • V. D. Rozumenko,
  • A. Ya. Glavatsky,
  • N. G. Chopick,
  • N. P. Olexenko,
  • E. S. Galanta,
  • O. I. Tsyubko,
  • N. D. Snitsar

DOI
https://doi.org/10.25305/unj.108009
Journal volume & issue
no. 4
pp. 36 – 40

Abstract

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Glutathione S-transferases common activity, genotypes of glutathione transferases mu and theta and also levels of glutathione transferase pi expression in human brain gliomas (80 samples: 10 low-grade diffuse astrocytomas, 19 anaplastic astrocytomas, 37 glioblastomas, 9 oligodendroastrocytomas, 5 oligodendrogliomas) of different malignancy grade were investigated. The results of conducted researches testified that functional polymorphism of GSTP1 glutathione S-transferases activity correlated with gliomas malignancy grade. Structural polymorphism of GSTM1 and GSTT1 did not depend on the malignancy grade. However, it was set that GSTМ1“0”-genotype presence was more frequent in astrocytomas. Thus, for effective chemotherapy it is necessary to take into account individual features of glutathione transferases dependent chemoresistance.