Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy

Maria P. Cabral; Patricia García; Alejandro Beceiro; Carlos Rumbo; Astrid Pérez; Miriam Moscoso; Germán Bou

doi:10.1038/ncomms15480

Nature Communications (May 2017)

Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy

Maria P. Cabral,
Patricia García,
Alejandro Beceiro,
Carlos Rumbo,
Astrid Pérez,
Miriam Moscoso,
Germán Bou

Affiliations

Maria P. Cabral: Microbiology Department, University Hospital A Coruña (CHUAC)–Biomedical Research Institute A Coruña (INIBIC)
Patricia García: Microbiology Department, University Hospital A Coruña (CHUAC)–Biomedical Research Institute A Coruña (INIBIC)
Alejandro Beceiro: Microbiology Department, University Hospital A Coruña (CHUAC)–Biomedical Research Institute A Coruña (INIBIC)
Carlos Rumbo: Microbiology Department, University Hospital A Coruña (CHUAC)–Biomedical Research Institute A Coruña (INIBIC)
Astrid Pérez: Microbiology Department, University Hospital A Coruña (CHUAC)–Biomedical Research Institute A Coruña (INIBIC)
Miriam Moscoso: Microbiology Department, University Hospital A Coruña (CHUAC)–Biomedical Research Institute A Coruña (INIBIC)
Germán Bou: Microbiology Department, University Hospital A Coruña (CHUAC)–Biomedical Research Institute A Coruña (INIBIC)

DOI: https://doi.org/10.1038/ncomms15480
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 17

Abstract

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D-glutamate is an essential component of the bacterial cell wall. Here, the authors use mouse models of infection withAcinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureusto show that bacterial mutants unable to synthesize D-glutamate can potentially be used as live attenuated vaccines.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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