New analysis of clopidogrel bisulfate in plavix tablet and human biological fluids utilizing chemically modified carbon paste sensor

Abstract

The fabrication and the performance response characteristics of a sensitive, selective, simple, and rapid sensor for the determination of clopidogrel bisulfate (CLO-H2SO4) were described. The constructed carbon paste sensor comprised of an ion-pair based on clopidogrel with silicotungstate (CLO-ST) where this study included: composition, usable pH range, response time and temperature. The sensor exhibited a wide linear dynamic concentration ranging from 1.00 × 10−7 to 1.00 × 10−2 and the usable pH ranges from 1.2 to 4.8 with the response time ranging from 5 to 8 s which is much faster compared to liquid ISEs with a detection limit equalling 0.34 nM. The selectivity of the sensor (CLO-H2SO4) was applied with respect to many of organic and inorganic cations, amino acids and sugars. The sensor had applications in bulk powder, tablets, humans (serum-urine) and in monitoring Plavix tablets’ dissolution rates. The obtained results were statistically analyzed for both accuracy and precision and were compared using the US pharmacopeial method where no significant difference was observed. Keywords: Clopidogrel bisulfate (CLO-H2SO4), Carbon-paste sensor, Potentiometry, Dissolution rate