The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells

Gennaro Gambardella; Annamaria Carissimo; Amy Chen; Luisa Cutillo; Tomasz J. Nowakowski; Diego di Bernardo; Robert Blelloch

doi:10.1038/ncomms14126

Nature Communications (Jan 2017)

The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells

Gennaro Gambardella,
Annamaria Carissimo,
Amy Chen,
Luisa Cutillo,
Tomasz J. Nowakowski,
Diego di Bernardo,
Robert Blelloch

Affiliations

Gennaro Gambardella: Telethon Institute of Genetics and Medicine
Annamaria Carissimo: Telethon Institute of Genetics and Medicine
Amy Chen: The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California
Luisa Cutillo: Telethon Institute of Genetics and Medicine
Tomasz J. Nowakowski: The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California
Diego di Bernardo: Telethon Institute of Genetics and Medicine
Robert Blelloch: The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California

DOI: https://doi.org/10.1038/ncomms14126
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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MicroRNAs can posttranscriptionally repress multiple targets in a cell population. Here the authors use single-cell sequencing to investigate the effects of an individual miRNA on transcriptional heterogeneity and gene co-expression

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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