Functional cis-regulatory modules encoded by mouse-specific endogenous retrovirus

Vasavi Sundaram; Mayank N. K. Choudhary; Erica Pehrsson; Xiaoyun Xing; Christopher Fiore; Manishi Pandey; Brett Maricque; Methma Udawatta; Duc Ngo; Yujie Chen; Asia Paguntalan; Tammy Ray; Ava Hughes; Barak A. Cohen; Ting Wang

doi:10.1038/ncomms14550

Nature Communications (Mar 2017)

Functional cis-regulatory modules encoded by mouse-specific endogenous retrovirus

Vasavi Sundaram,
Mayank N. K. Choudhary,
Erica Pehrsson,
Xiaoyun Xing,
Christopher Fiore,
Manishi Pandey,
Brett Maricque,
Methma Udawatta,
Duc Ngo,
Yujie Chen,
Asia Paguntalan,
Tammy Ray,
Ava Hughes,
Barak A. Cohen,
Ting Wang

Affiliations

Vasavi Sundaram: Division of Biological and Biomedical Sciences, Washington University School of Medicine
Mayank N. K. Choudhary: Division of Biological and Biomedical Sciences, Washington University School of Medicine
Erica Pehrsson: Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine
Xiaoyun Xing: Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine
Christopher Fiore: Division of Biological and Biomedical Sciences, Washington University School of Medicine
Manishi Pandey: Division of Biological and Biomedical Sciences, Washington University School of Medicine
Brett Maricque: Division of Biological and Biomedical Sciences, Washington University School of Medicine
Methma Udawatta: Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine
Duc Ngo: Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine
Yujie Chen: Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine
Asia Paguntalan: Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine
Tammy Ray: Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine
Ava Hughes: Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine
Barak A. Cohen: Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine
Ting Wang: Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine

DOI: https://doi.org/10.1038/ncomms14550
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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The gene-battery model posits transposable elements (TEs) may becis-regulatory elements to control gene expression. Here, mouse-specific TEs are shown as binding sites for multiple collaborating transcription factors in embryonic stem cells, and act as cis-regulatory modules in synergistic fashion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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