In Search of Selectivity: Design, Synthesis, and Biological Evaluation of New Classes of HDAC Inhibitors

L. M. Viranga Tillekeratne; Ayad Ayad Al-Hamashi; Samkeliso Dlamini; William Taylor; Radhika Koranne; Mary Kay Pflum; Ahmed T. Negmeldin; Joseph Knoff

doi:10.3390/proceedings2019022063

Proceedings (Aug 2019)

In Search of Selectivity: Design, Synthesis, and Biological Evaluation of New Classes of HDAC Inhibitors

L. M. Viranga Tillekeratne,
Ayad Ayad Al-Hamashi,
Samkeliso Dlamini,
William Taylor,
Radhika Koranne,
Mary Kay Pflum,
Ahmed T. Negmeldin,
Joseph Knoff

Affiliations

L. M. Viranga Tillekeratne: Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43606, USA
Ayad Ayad Al-Hamashi: Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43606, USA
Samkeliso Dlamini: Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43606, USA
William Taylor: Department of Biological Sciences, College of Natural Sciences and Mathematics, University of Toledo, Toledo, OH 43606, USA
Radhika Koranne: Department of Biological Sciences, College of Natural Sciences and Mathematics, University of Toledo, Toledo, OH 43606, USA
Mary Kay Pflum: Department of Chemistry, College of Liberal Arts and Sciences, Wayne State University, Detroit, MI 48202, USA
Ahmed T. Negmeldin: Department of Chemistry, College of Liberal Arts and Sciences, Wayne State University, Detroit, MI 48202, USA
Joseph Knoff: Department of Chemistry, College of Liberal Arts and Sciences, Wayne State University, Detroit, MI 48202, USA

DOI: https://doi.org/10.3390/proceedings2019022063
Journal volume & issue: Vol. 22, no. 1
p. 63

Abstract

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Epigenetic regulation of gene expression without changing DNA sequences is a promising strategy in developing therapeutic agents for human diseases, especially cancer. [...]

Published in Proceedings

ISSN: 2504-3900 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: General Works
Website: http://www.mdpi.com/journal/proceedings

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