Efferocytosis requires periphagosomal Ca2+-signaling and TRPM7-mediated electrical activity

Michael S. Schappe; Marta E. Stremska; Gregory W. Busey; Taylor K. Downs; Philip V. Seegren; Suresh K. Mendu; Zachary Flegal; Catherine A. Doyle; Eric J. Stipes; Bimal N. Desai

doi:10.1038/s41467-022-30959-4

Nature Communications (Jun 2022)

Efferocytosis requires periphagosomal Ca2+-signaling and TRPM7-mediated electrical activity

Michael S. Schappe,
Marta E. Stremska,
Gregory W. Busey,
Taylor K. Downs,
Philip V. Seegren,
Suresh K. Mendu,
Zachary Flegal,
Catherine A. Doyle,
Eric J. Stipes,
Bimal N. Desai

Affiliations

Michael S. Schappe: Pharmacology Department, University of Virginia
Marta E. Stremska: Pharmacology Department, University of Virginia
Gregory W. Busey: Pharmacology Department, University of Virginia
Taylor K. Downs: Pharmacology Department, University of Virginia
Philip V. Seegren: Pharmacology Department, University of Virginia
Suresh K. Mendu: Pharmacology Department, University of Virginia
Zachary Flegal: Pharmacology Department, University of Virginia
Catherine A. Doyle: Pharmacology Department, University of Virginia
Eric J. Stipes: Pharmacology Department, University of Virginia
Bimal N. Desai: Pharmacology Department, University of Virginia

DOI: https://doi.org/10.1038/s41467-022-30959-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Efficient removal of apoptotic cells by phagocytosis underlies tissue development, wound repair, host defense and organ homeostasis. Here, authors identify TRPM7 as a regulator of cargo acidification and Ca2+ signaling during apoptotic cell clearance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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