Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly(ADP-ribose) Polymerase‑1 Inhibitors with Decreased P‑Glycoprotein Interactions

• Sean W. Reilly,
• Laura N. Puentes,
• Chia-Ju Hsieh,
• Mehran Makvandi,
• Robert H. Mach

Affiliations

Sean W. Reilly

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Laura N. Puentes

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Chia-Ju Hsieh

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Mehran Makvandi

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Robert H. Mach

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States