Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова (Jun 2016)

С(-344)Т polymorphism of aldosterone synthase gene, risk of metabolic syndrome, and atrial fibrillation risk for inhabitants of the Northwest regions of Russia

  • I. Ma,
  • A. S. Ulitina,
  • V. A. Ionin,
  • E. L. Zaslavskaya,
  • V. V. Miroshnikova,
  • A. A. Panteleeva,
  • O. D. Belyaeva,
  • E. A. Bazhenova,
  • O A. Berkovich,
  • S. N. Pchelina,
  • E. I. Baranova

Journal volume & issue
Vol. 23, no. 2
pp. 46 – 49

Abstract

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Objective: to estimate contribution of C(-344)T version of aldosterone synthase CYP11B2 gene in risk of metabolic syndrome (MS) and atrial fibrillation (AF) for inhabitants of the Northwest region of Russia. Material and methods: 199 patients with MS, 103 from them with AF and 267 healthy persons. Identification of C-344T gene of CYP11B2 aldosterone sinthase has been performed by means of PCR method with restriction analysis. Results: in MS carriership of TT (-344) genotype met more often than in control: 33.2 % and 24.3 %, respectively (p = 0.04). Carriership of TT (-344) genotype increases risk of MS: OR = 1.54 (95 % CI 1.03-2.32) and was not associated with an increased risk of AF. Conclusion: association of TT(-344) genotype of CYP11B2 gene with risk of metabolic syndrome for inhabitants of the Northwest region ofRussia is revealed.

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