Ferroptosis as a therapeutic target for inflammation-related intestinal diseases

Xiaoli Zhang; Xiaoli Zhang; Xiaoli Zhang; Yiming Ma; Guoqing Lv; Hongying Wang

doi:10.3389/fphar.2023.1095366

Frontiers in Pharmacology (Jan 2023)

Ferroptosis as a therapeutic target for inflammation-related intestinal diseases

Xiaoli Zhang,
Xiaoli Zhang,
Xiaoli Zhang,
Yiming Ma,
Guoqing Lv,
Hongying Wang

Affiliations

Xiaoli Zhang: State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Xiaoli Zhang: State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing, China
Xiaoli Zhang: Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, China
Yiming Ma: State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Guoqing Lv: Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Guangdong, China
Hongying Wang: State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

DOI: https://doi.org/10.3389/fphar.2023.1095366
Journal volume & issue: Vol. 14

Abstract

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Ferroptosis is an iron-dependent programmed cell death characterized by reactive oxygen species-induced lipid peroxidation and resultant membrane damage. Recent research has elucidated the mechanism of ferroptosis and investigated the relationship between ferroptosis and various diseases, including degenerative diseases, cancer, and inflammation. Ferroptosis is associated with inflammation-related intestinal diseases such as colitis and colitis-associated cancer. New insights into the role of ferroptosis in the pathogenesis of inflammation-related gut diseases have suggested novel therapeutic targets. In this review, we summarize current information on the molecular mechanisms of ferroptosis and describe its emerging role and therapeutic potential in inflammation-related intestinal diseases.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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Abstract

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