Frontiers in Immunology (Jun 2022)
Myeloid Cell Classification and Therapeutic Opportunities Within the Glioblastoma Tumor Microenvironment in the Single Cell-Omics Era
- Collin J. Larkin,
- Víctor A. Arrieta,
- Víctor A. Arrieta,
- Víctor A. Arrieta,
- Hinda Najem,
- Hinda Najem,
- Gongbo Li,
- Gongbo Li,
- Peng Zhang,
- Peng Zhang,
- Jason Miska,
- Jason Miska,
- Peiwen Chen,
- Peiwen Chen,
- Charles David James,
- Charles David James,
- Adam M. Sonabend,
- Adam M. Sonabend,
- Amy B. Heimberger,
- Amy B. Heimberger
Affiliations
- Collin J. Larkin
- Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Víctor A. Arrieta
- Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Víctor A. Arrieta
- Lou and Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Víctor A. Arrieta
- Programa de Estudios Combinados en Medicina (PECEM), Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico
- Hinda Najem
- Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Hinda Najem
- Lou and Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Gongbo Li
- Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Gongbo Li
- Lou and Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Peng Zhang
- Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Peng Zhang
- Lou and Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Jason Miska
- Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Jason Miska
- Lou and Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Peiwen Chen
- Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Peiwen Chen
- Lou and Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Charles David James
- Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Charles David James
- Lou and Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Adam M. Sonabend
- Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Adam M. Sonabend
- Lou and Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Amy B. Heimberger
- Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Amy B. Heimberger
- Lou and Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- DOI
- https://doi.org/10.3389/fimmu.2022.907605
- Journal volume & issue
-
Vol. 13
Abstract
The glioma tumor microenvironment (TME) is complex and heterogeneous, and multiple emerging and current technologies are being utilized for an improved comprehension and understanding of these tumors. Single cell analysis techniques such as single cell genomic and transcriptomic sequencing analysis are on the rise and play an important role in elucidating the glioma TME. These large datasets will prove useful for patient tumor characterization, including immune configuration that will ultimately influence therapeutic choices and especially immune therapies. In this review we discuss the advantages and drawbacks of these techniques while debating their role in the domain of glioma-infiltrating myeloid cells characterization and function.
Keywords
