Assessment of the relevance of osmolality measurement as a criterion for the stability of solutions

Abstract

The measurement of osmolality is used by many authors as an additional stability criterion of a drug in solution. In the current state of knowledge, no scientific publication correlates the osmolality values and the stability of a solution. To study the relevance of this analytical technique by measuring the osmolality of injectable solutions whose instability has been chemically demonstrated by high performance liquid chromatography (HPLC).

Keywords

• degradation
• osmolality
• stability