Frontiers in Neurology (Aug 2022)

Phase I/II trial of local interstitial chemotherapy with arsenic trioxide in patients with newly diagnosed glioma

  • Dayong Han,
  • Dayong Han,
  • Dayong Han,
  • Lei Teng,
  • Lei Teng,
  • Lei Teng,
  • Xiaoxiong Wang,
  • Xiaoxiong Wang,
  • Xiaoxiong Wang,
  • Yunbo Zhen,
  • Yunbo Zhen,
  • Yunbo Zhen,
  • Xiaofeng Chen,
  • Xiaofeng Chen,
  • Xiaofeng Chen,
  • Mingchun Yang,
  • Mingchun Yang,
  • Mingchun Yang,
  • Ming Gao,
  • Ming Gao,
  • Ming Gao,
  • Guang Yang,
  • Guang Yang,
  • Guang Yang,
  • Mingyang Han,
  • Ligang Wang,
  • Ligang Wang,
  • Ligang Wang,
  • Jiajun Xu,
  • Jiajun Xu,
  • Jiajun Xu,
  • Yue Li,
  • Alina Shumadalova,
  • Shiguang Zhao,
  • Shiguang Zhao,
  • Shiguang Zhao,
  • Shiguang Zhao

DOI
https://doi.org/10.3389/fneur.2022.1001829
Journal volume & issue
Vol. 13

Abstract

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BackgroundGlioma is the most common primary brain tumor in adults with poor prognosis. The glioma patients benefit from STUPP strategy, including maximum and safe resection and adjuvant radiotherapy and chemotherapy. Arsenic trioxide could inhibit various tumors. However, it is a challenge to evaluate the efficiency and safety of srsenic trioxide in glioma patients.ObjectiveThe arsenic trioxide has the potent therapeutic effect on glioma. However, the safety and efficacy of local interstitial chemotherapy with arsenic trioxide in newly diagnosed glioma patients is unclear.MethodsAll patients received partial or complete tumor resection and intraoperative implantation of Ommaya reservoirs followed by standard radiotherapy. Arsenic trioxide with the starting dose 0.3 mg was administered via an Ommaya reservoir catheter inserted into the tumor cavity for 5 consecutive days every 3 months for a total of eight cycles unless tumor progression or excessive toxicity was observed.ResultsNo hematological or grade 4 non-hematological toxicity was observed in any patient during arsenic trioxide treatment. The maximum tolerated dose of 1.5 mg of arsenic trioxide was safe and well tolerated. The median overall survival for WHO grade 3 glioma was 33.6 months, and for glioblastoma was 13.9 months. The median progression-free survival for WHO grade 2 glioma was 40.3 months, for grade 3 glioma was 21.5 months, and for glioblastoma was 9.5 months.ConclusionThese results suggest that arsenic trioxide is safe and well tolerated with local delivery into the tumor cavity of the brain, and the dose recommended for a phase II trial is 1.5 mg.

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