NMR and Metabolomics—A Roadmap for the Future

David S. Wishart; Leo L. Cheng; Valérie Copié; Arthur S. Edison; Hamid R. Eghbalnia; Jeffrey C. Hoch; Goncalo J. Gouveia; Wimal Pathmasiri; Robert Powers; Tracey B. Schock; Lloyd W. Sumner; Mario Uchimiya

doi:10.3390/metabo12080678

Metabolites (Jul 2022)

NMR and Metabolomics—A Roadmap for the Future

David S. Wishart,
Leo L. Cheng,
Valérie Copié,
Arthur S. Edison,
Hamid R. Eghbalnia,
Jeffrey C. Hoch,
Goncalo J. Gouveia,
Wimal Pathmasiri,
Robert Powers,
Tracey B. Schock,
Lloyd W. Sumner,
Mario Uchimiya

Affiliations

David S. Wishart: Departments of Biological Sciences and Computing Science, University of Alberta, Edmonton, AB T6G 2E9, Canada
Leo L. Cheng: Department of Pathology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Valérie Copié: Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59715, USA
Arthur S. Edison: Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA
Hamid R. Eghbalnia: Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT 06030-3305, USA
Jeffrey C. Hoch: Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT 06030-3305, USA
Goncalo J. Gouveia: Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA
Wimal Pathmasiri: Nutrition Research Institute, Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Robert Powers: Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304, USA
Tracey B. Schock: National Institute of Standards and Technology (NIST), Chemical Sciences Division, Charleston, SC 29412, USA
Lloyd W. Sumner: Interdisciplinary Plant Group, MU Metabolomics Center, Bond Life Sciences Center, Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
Mario Uchimiya: Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA

DOI: https://doi.org/10.3390/metabo12080678
Journal volume & issue: Vol. 12, no. 8
p. 678

Abstract

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Metabolomics investigates global metabolic alterations associated with chemical, biological, physiological, or pathological processes. These metabolic changes are measured with various analytical platforms including liquid chromatography-mass spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR). While LC-MS methods are becoming increasingly popular in the field of metabolomics (accounting for more than 70% of published metabolomics studies to date), there are considerable benefits and advantages to NMR-based methods for metabolomic studies. In fact, according to PubMed, more than 926 papers on NMR-based metabolomics were published in 2021—the most ever published in a given year. This suggests that NMR-based metabolomics continues to grow and has plenty to offer to the scientific community. This perspective outlines the growing applications of NMR in metabolomics, highlights several recent advances in NMR technologies for metabolomics, and provides a roadmap for future advancements.

Published in Metabolites

ISSN: 2218-1989 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/metabolites

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