Nature Communications (Sep 2018)
A high throughput screen for next-generation leads targeting malaria parasite transmission
- Michael J. Delves,
- Celia Miguel-Blanco,
- Holly Matthews,
- Irene Molina,
- Andrea Ruecker,
- Sabrina Yahiya,
- Ursula Straschil,
- Matthew Abraham,
- María Luisa León,
- Oliver J. Fischer,
- Ainoa Rueda-Zubiaurre,
- Jochen R. Brandt,
- Álvaro Cortés,
- Anna Barnard,
- Matthew J. Fuchter,
- Félix Calderón,
- Elizabeth A. Winzeler,
- Robert E. Sinden,
- Esperanza Herreros,
- Francisco J. Gamo,
- Jake Baum
Affiliations
- Michael J. Delves
- Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building
- Celia Miguel-Blanco
- Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building
- Holly Matthews
- Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building
- Irene Molina
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Andrea Ruecker
- Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building
- Sabrina Yahiya
- Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building
- Ursula Straschil
- Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building
- Matthew Abraham
- School of Medicine, University of California San Diego
- María Luisa León
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Oliver J. Fischer
- Department of Chemistry, Imperial College London
- Ainoa Rueda-Zubiaurre
- Department of Chemistry, Imperial College London
- Jochen R. Brandt
- Department of Chemistry, Imperial College London
- Álvaro Cortés
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Anna Barnard
- Department of Chemistry, Imperial College London
- Matthew J. Fuchter
- Department of Chemistry, Imperial College London
- Félix Calderón
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Elizabeth A. Winzeler
- School of Medicine, University of California San Diego
- Robert E. Sinden
- Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building
- Esperanza Herreros
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Francisco J. Gamo
- Diseases of the Developing World (DDW), GlaxoSmithKline
- Jake Baum
- Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building
- DOI
- https://doi.org/10.1038/s41467-018-05777-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Sexual forms of malaria parasites are responsible for transmission to the mosquito. Anti-malarial drug resistance remains a serious problem and requires advent of new drug therapies. Here, the authors present a high-throughput screen of potential antimalarial compounds, identifying seventeen drug-like molecules specifically targeting transmission.
