Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Rana Salam; Alexa Saliou; Franck Bielle; Mathilde Bertrand; Christophe Antoniewski; Catherine Carpentier; Agusti Alentorn; Laurent Capelle; Marc Sanson; Emmanuelle Huillard; Léa Bellenger; Justine Guégan; Isabelle Le Roux

doi:10.1038/s41467-023-36124-9

Nature Communications (Jan 2023)

Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Rana Salam,
Alexa Saliou,
Franck Bielle,
Mathilde Bertrand,
Christophe Antoniewski,
Catherine Carpentier,
Agusti Alentorn,
Laurent Capelle,
Marc Sanson,
Emmanuelle Huillard,
Léa Bellenger,
Justine Guégan,
Isabelle Le Roux

Affiliations

Rana Salam: Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors Team
Alexa Saliou: Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors Team
Franck Bielle: Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors Team
Mathilde Bertrand: Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Data Analysis Core Platform
Christophe Antoniewski: Sorbonne Université, CNRS FR3631, Inserm US037, Institut de Biologie Paris Seine (IBPS), ARTbio Bioinformatics Analysis Facility, Paris, Institut Français de Bioinformatique (IFB)
Catherine Carpentier: Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors Team
Agusti Alentorn: Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors Team
Laurent Capelle: AP-HP, Hôpital de la Pitié-Salpêtrière—Charles Foix, Service de Neurochirurgie
Marc Sanson: Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors Team
Emmanuelle Huillard: Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors Team
Léa Bellenger: Sorbonne Université, CNRS FR3631, Inserm US037, Institut de Biologie Paris Seine (IBPS), ARTbio Bioinformatics Analysis Facility, Paris, Institut Français de Bioinformatique (IFB)
Justine Guégan: Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Data Analysis Core Platform
Isabelle Le Roux: Paris Brain Institute (ICM), Hôpital Pitié-Salpêtrière, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Genetics and Development of Brain Tumors Team

DOI: https://doi.org/10.1038/s41467-023-36124-9
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 21

Abstract

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Senescence can have beneficial and detrimental impact on cancer progression depending on the cellular context. Here the authors show that NRF2 regulates the senescence phenotype in malignant cells which consequently contribute to glioblastoma progression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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