Research progress on aging related factors and delaying measures for aging of female germ line stem cells

Abstract

In recent years, female germ line stem cells (FGSCs) in mammals have attracted much attention because of their contribution to follicular renewal and fertility maintenance/restoration, but their aging mechanism and preventive measures are still unclear. Studies have shown that the microenvironment changes in FGSCs nests, such as immune disorder, chronic inflammation and oxidative stress, can lead to the aging and plummeting of FGSCs through the mediation of relevant signaling pathways and genes. Therefore, the regulation of immune dysfunction, anti-inflammation and oxidative stress, and potential intervention to related signaling pathways as well as genes expression are expected to have some effect on slowing down FGSCs aging process.

Keywords

• female germline stem cells|aging factors|delaying measures