Mobilization success rate following autologous peripheral blood stem cell transplantation

Abstract

Aim:If there issuccessful mobilization following a conditioning regimen forstem cell transplantation, the in vivo purged stem cell products may be collected for a second transplantation.Materials and Methods:In this prospective study, peripheral blood CD34+ cells were quantified between 6th day after stem cell infusion and 3rdday after neutrophil engraftment in 20 patients using flow cytometry. Results:In the autologous peripheral blood stem cell transplantation (auto-PBSCT)group(n= 16), the CD34+ cell count was lowest during the first 10 days. The median CD34+ cell count began to increase at the 11th day and the highest value was achieved at the 14th day. We documented evidence of mobilization in only one patient (6.25%). Conclusion:Our results indicate thatthe rate of successful stem cell mobilization is very lowfollowing auto-PBSCT. In conclusion, collecting CD34+ stem cells following the first auto-PBSCT is not an effective method for tandem transplantation.

Keywords

• cd 34+ hücre düzeyleri
• mobilizasyon
• cd34+ cell levels
• mobilization