Nature Communications (Jan 2022)

Hypocrates is a genetically encoded fluorescent biosensor for (pseudo)hypohalous acids and their derivatives

  • Alexander I. Kostyuk,
  • Maria-Armineh Tossounian,
  • Anastasiya S. Panova,
  • Marion Thauvin,
  • Roman I. Raevskii,
  • Daria Ezeriņa,
  • Khadija Wahni,
  • Inge Van Molle,
  • Anastasia D. Sergeeva,
  • Didier Vertommen,
  • Andrey Yu. Gorokhovatsky,
  • Mikhail S. Baranov,
  • Sophie Vriz,
  • Joris Messens,
  • Dmitry S. Bilan,
  • Vsevolod V. Belousov

DOI
https://doi.org/10.1038/s41467-021-27796-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

There are a lack of tools to study the dynamics of (pseudo)hypohalous acids in live cells. Here the authors report a genetically encoded fluorescent biosensor, Hypocrates, for (pseudo)hypohalous acids and their derivatives which they use in cells and in a zebrafish tail fin injury model.