Nature Communications (Jan 2019)
BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation
- Antoine Campagne,
- Ming-Kang Lee,
- Dina Zielinski,
- Audrey Michaud,
- Stéphanie Le Corre,
- Florent Dingli,
- Hong Chen,
- Lara Z. Shahidian,
- Ivaylo Vassilev,
- Nicolas Servant,
- Damarys Loew,
- Eric Pasmant,
- Sophie Postel-Vinay,
- Michel Wassef,
- Raphaël Margueron
Affiliations
- Antoine Campagne
- Institut Curie, Paris Sciences et Lettres Research University, Sorbonne University
- Ming-Kang Lee
- Institut Curie, Paris Sciences et Lettres Research University, Sorbonne University
- Dina Zielinski
- Institut Curie, Paris Sciences et Lettres Research University, Sorbonne University
- Audrey Michaud
- Institut Curie, Paris Sciences et Lettres Research University, Sorbonne University
- Stéphanie Le Corre
- Institut Curie, Paris Sciences et Lettres Research University, Sorbonne University
- Florent Dingli
- Institut Curie, Paris Sciences et Lettres Research University, Sorbonne University
- Hong Chen
- Institut Curie, Paris Sciences et Lettres Research University, Sorbonne University
- Lara Z. Shahidian
- Institute of Functional Epigenetics, Helmholtz Zentrum München
- Ivaylo Vassilev
- Institut Curie, Paris Sciences et Lettres Research University, Sorbonne University
- Nicolas Servant
- Institut Curie, Paris Sciences et Lettres Research University, Sorbonne University
- Damarys Loew
- Institut Curie, Paris Sciences et Lettres Research University, Sorbonne University
- Eric Pasmant
- Department of Molecular Genetics Pathology, Cochin Hospital, HUPC AP-HP, EA7331, Faculty of Pharmacy, University of Paris Descartes
- Sophie Postel-Vinay
- Département d’Innovation Thérapeutique et Essais Précoces, INSERM U981, Gustave Roussy, Université Paris-Saclay
- Michel Wassef
- Institut Curie, Paris Sciences et Lettres Research University, Sorbonne University
- Raphaël Margueron
- Institut Curie, Paris Sciences et Lettres Research University, Sorbonne University
- DOI
- https://doi.org/10.1038/s41467-018-08255-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
In Drosophila, the Calypso–ASX complex catalyzes H2A deubiquitination and aids Polycomb in transcriptional silencing. Here the authors show that the orthologous complex, BAP1.com, promotes gene activation by counteracting PRC1-mediated gene silencing.
