Panax ginseng leaf aqueous extract mediated green synthesis of AgNPs under ultrasound condition and investigation of its anti-lung adenocarcinoma effects

Abstract

Panax ginseng has many therapeutic uses in medicine. In the recent research, silver nanoparticles (AgNPs) were formulated by the Panax ginseng aqueous extract. The synthesized AgNPs’ characterization was analyzed using UV-Vis spectrophotometry, energy dispersive X-ray spectroscopy, scanning electron microscopy, fourier transformed infrared spectroscopy, transmission electron microscopy, and elemental mapping. The AgNPs were analyzed for their surface morphology by SEM. The successful synthesis of AgNPs was evident with TEM images. The AgNPs had a uniform distribution and homogenous spherical shaped morphology with mean diameter in the range of 20–30 nm. The cytotoxic and anti-lung adenocarcinoma ‎potentials of biologically formulated AgNPs‎ against NCI-H1563‎, NCI-H1437‎, NCI-H1299‎, and NCI-H2126 cells were determined. The anti-lung adenocarcinoma ‎ properties of the AgNPs ‎ removed NCI-H1563‎, NCI-H1437‎, NCI-H1299‎, and NCI-H2126 cells. The AgNPs’ IC50‎ were 193, 156, 250, and 278 µg/mL against NCI-H1563‎, NCI-H1437‎, NCI-H1299‎, and NCI-H2126 cells, respectively. Also, AgNPs presented high antioxidant potential.

Keywords

• agnps
• panax ginseng leaf
• lung carcinoma