Beilstein Journal of Organic Chemistry (Mar 2014)
Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide
Abstract
Here we describe the use of a new open-source software package and a Raspberry Pi® computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide – a component of Rifater®, used in the treatment of tuberculosis – and its reduced derivative piperazine-2-carboxamide.
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