Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Abstract

Here we describe the use of a new open-source software package and a Raspberry Pi® computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide – a component of Rifater®, used in the treatment of tuberculosis – and its reduced derivative piperazine-2-carboxamide.

Keywords

• automation
• flow chemistry
• hydration
• hydrogenation
• sustainable processing