Nature Communications (Jul 2019)

β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer

  • Piera Tocci,
  • Roberta Cianfrocca,
  • Valeriana Di Castro,
  • Laura Rosanò,
  • Andrea Sacconi,
  • Sara Donzelli,
  • Silvia Bonfiglio,
  • Gabriele Bucci,
  • Enrico Vizza,
  • Gabriella Ferrandina,
  • Giovanni Scambia,
  • Giovanni Tonon,
  • Giovanni Blandino,
  • Anna Bagnato

DOI
https://doi.org/10.1038/s41467-019-11045-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

YAP and mutant p53 crosstalk to regulate transcriptional processes in cancers. Here, the authors show that endothelin-1 mediated activation of β-arrestin interacts with YAP to recruit mutant p53 to the TEAD/YAP complex to promote metastasis and chemoresistance in ovarian cancer.