Frequency of various factors affecting pregnancy loss in patients with history of recurrent pregnancy loss in Sistan and Balouchestan province, 2017-2018

Abstract

Introduction: Recurrent pregnancy loss refers to the occurrence of two or more consecutive abortions before the 20th week of pregnancy, which has a high prevalence and it is necessary to identify the factors affecting it. Therefore, this study was performed with aim to investigate the frequency of various factors affecting pregnancy loss in patients with history of recurrent pregnancy loss. Methods: This cross-sectional study was performed on 280 women with at least two abortions less than 20 weeks who had referred to the only infertility treatment center in Sistan and Balouchestan province in 2017-2018. Data related to abortion was collected based on the patients' file. Data were analyzed using SPSS software (version 20) and Kolmogorov-Smirnov test with lilliefors correction, Student t, Mann-Whitney and Fisher's exact tests. P<0.05 was considered statistically significant. Results: The most common causes of recurrent pregnancy loss included: uterus anatomical abnormalities (44.64%) and then spontaneous abortion with unexplained causes (38.93%). Endocrine causes (35%), male causes (6.43%), chronic endometritis (8.21%), genetic causes (3.57%), inherited thrombophilia (2.86%), and immunological causes (1.43%) were in the next ranks.. Conclusion: The most common disorders leading to recurrent abortions in Moloud Infertility Center of Zahedan were uterus anatomical disorders (44.46%) and then spontaneous abortions with unknown causes (38.93%) but endocrine disorders (35%) was the next most common cause. In case of timely diagnosis and treatment, it may be possible to reduce the rate of recurrent abortion.

Keywords

• anatomical disorders
• endocrine
• endometritis
• inherited thrombophilia
• recurrent pregnancy loss