Nature Communications (Sep 2018)

GraphDDP: a graph-embedding approach to detect differentiation pathways in single-cell-data using prior class knowledge

  • Fabrizio Costa,
  • Dominic Grün,
  • Rolf Backofen

DOI
https://doi.org/10.1038/s41467-018-05988-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 8

Abstract

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Inference and representation of differentiation trajectories from single cell RNA-seq data remains a challenge. Here, the authors offer a visualization approach that captures both continuous differentiation trajectories and discrete clusters representing metastable states along the trajectories.