Nature Communications (Aug 2018)
Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species
- Angeliki M. Andrianaki,
- Irene Kyrmizi,
- Kalliopi Thanopoulou,
- Clara Baldin,
- Elias Drakos,
- Sameh S. M. Soliman,
- Amol C. Shetty,
- Carrie McCracken,
- Tonia Akoumianaki,
- Kostas Stylianou,
- Petros Ioannou,
- Charalampos Pontikoglou,
- Helen A. Papadaki,
- Maria Tzardi,
- Valerie Belle,
- Emilien Etienne,
- Anne Beauvais,
- George Samonis,
- Dimitrios P. Kontoyiannis,
- Evangelos Andreakos,
- Vincent M. Bruno,
- Ashraf S. Ibrahim,
- Georgios Chamilos
Affiliations
- Angeliki M. Andrianaki
- Department of Medicine, University of Crete, Foundation for Research and Technology
- Irene Kyrmizi
- Department of Medicine, University of Crete, Foundation for Research and Technology
- Kalliopi Thanopoulou
- Laboratory of Immunobiology, Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens
- Clara Baldin
- Division of Infectious Diseases, Los Angeles Biomedical Research Institute, Harbor-University of California Los Angeles (UCLA) Medical Center
- Elias Drakos
- Department of Medicine, University of Crete, Foundation for Research and Technology
- Sameh S. M. Soliman
- Sharjah Institute for Medical Research, College of Pharmacy, University of Sharjah
- Amol C. Shetty
- Institute for Genome Sciences, University of Maryland School of Medicine
- Carrie McCracken
- Institute for Genome Sciences, University of Maryland School of Medicine
- Tonia Akoumianaki
- Department of Medicine, University of Crete, Foundation for Research and Technology
- Kostas Stylianou
- Department of Medicine, University of Crete, Foundation for Research and Technology
- Petros Ioannou
- Department of Medicine, University of Crete, Foundation for Research and Technology
- Charalampos Pontikoglou
- Department of Medicine, University of Crete, Foundation for Research and Technology
- Helen A. Papadaki
- Department of Medicine, University of Crete, Foundation for Research and Technology
- Maria Tzardi
- Department of Medicine, University of Crete, Foundation for Research and Technology
- Valerie Belle
- CNRS, BIP (UMR 7281), IMM (FR 3479), Aix-Marseille Université
- Emilien Etienne
- CNRS, BIP (UMR 7281), IMM (FR 3479), Aix-Marseille Université
- Anne Beauvais
- Unité des Aspergillus, Institut Pasteur
- George Samonis
- Department of Medicine, University of Crete, Foundation for Research and Technology
- Dimitrios P. Kontoyiannis
- Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center
- Evangelos Andreakos
- Laboratory of Immunobiology, Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens
- Vincent M. Bruno
- Institute for Genome Sciences, University of Maryland School of Medicine
- Ashraf S. Ibrahim
- Division of Infectious Diseases, Los Angeles Biomedical Research Institute, Harbor-University of California Los Angeles (UCLA) Medical Center
- Georgios Chamilos
- Department of Medicine, University of Crete, Foundation for Research and Technology
- DOI
- https://doi.org/10.1038/s41467-018-05820-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
Mucormycosis is a life-threatening respiratory fungal infection that typically occurs in patients with abnormalities in iron metabolism. Here the authors show that iron restriction inside the phagosome of macrophages is an essential component of the host defense against Rhizopus, the main species causing mucormycosis.
