Nature Communications (Apr 2022)
Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity
- Reuben Franklin,
- Yiming Guo,
- Shiyang He,
- Meijuan Chen,
- Fei Ji,
- Xinyue Zhou,
- David Frankhouser,
- Brian T. Do,
- Carmen Chiem,
- Mihyun Jang,
- M. Andres Blanco,
- Matthew G. Vander Heiden,
- Russell C. Rockne,
- Maria Ninova,
- David B. Sykes,
- Konrad Hochedlinger,
- Rui Lu,
- Ruslan I. Sadreyev,
- Jernej Murn,
- Andrew Volk,
- Sihem Cheloufi
Affiliations
- Reuben Franklin
- Department of Biochemistry, University of California, Riverside
- Yiming Guo
- Department of Biochemistry, University of California, Riverside
- Shiyang He
- Department of Biochemistry, University of California, Riverside
- Meijuan Chen
- Department of Biochemistry, University of California, Riverside
- Fei Ji
- Department of Molecular Biology, Massachusetts General Hospital
- Xinyue Zhou
- Division of Hematology/Oncology, O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham
- David Frankhouser
- Department of Population Sciences City of Hope National Medical Center
- Brian T. Do
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Carmen Chiem
- Department of Biochemistry, University of California, Riverside
- Mihyun Jang
- Department of Computational and Quantitative Medicine, Division of Mathematical Oncology, City of Hope National Medical Center
- M. Andres Blanco
- Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania
- Matthew G. Vander Heiden
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Russell C. Rockne
- Department of Computational and Quantitative Medicine, Division of Mathematical Oncology, City of Hope National Medical Center
- Maria Ninova
- Department of Biochemistry, University of California, Riverside
- David B. Sykes
- Center for Regenerative Medicine, Massachusetts General Hospital
- Konrad Hochedlinger
- Department of Molecular Biology, Massachusetts General Hospital
- Rui Lu
- Division of Hematology/Oncology, O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham
- Ruslan I. Sadreyev
- Department of Molecular Biology, Massachusetts General Hospital
- Jernej Murn
- Department of Biochemistry, University of California, Riverside
- Andrew Volk
- Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center
- Sihem Cheloufi
- Department of Biochemistry, University of California, Riverside
- DOI
- https://doi.org/10.1038/s41467-022-29730-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Cell fate commitment involves transcription factor activity and changes in chromatin architecture. Here the authors show that CAF-1 maintains lineage fidelity by controlling chromatin accessibility at specific sites; suppressing CAF-1 triggers differentiation of myeloid stem and progenitor cells into a mixed lineage state.
