eJHaem (Oct 2024)

Mixed autoimmune hemolytic anemia as the initial presentation of systemic lupus erythematosus: A case report and review

  • Brian P. Edwards,
  • Sidhartha Gautam Senapati,
  • Mariia Kasianchyk,
  • Joel Shah,
  • Fatih Ayvali,
  • Satish Maharaj

DOI
https://doi.org/10.1002/jha2.1008
Journal volume & issue
Vol. 5, no. 5
pp. 1053 – 1056

Abstract

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Abstract Autoimmune hemolytic anemia (AIHA) is an acquired condition caused by autoantibody mediated destruction of erythrocytes. AIHA is classified as warm or cold depending on whether the autoantibodies involved react optimally at or below body temperature (37°C), respectively. Mixed AIHA, with features of both, is rare and clinically more severe. We report a case of mixed AIHA that was found to be the presentation of systemic lupus erythematosus (SLE). Treatment with rituximab and prednisone resulted in good response. Although more commonly associated with warm AIHA, SLE can present with mixed AIHA.

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