DISTRIBUTION OF BIOCHEMICAL AND MOLECULAR-GENETIC MARKERS OF GENES IN WORKERS OF COAL MINING ENTERPRISES OF KUZBASS REGION SUFFERING FROM CHRONIC DUST BRONCHITIS

V. V. Zakharenkov; N. I. Gafarov; N. I. Panev; A. N. Kucher; M. B. Freydin; A. A. Rudko; T. K. Yadikina; A. S. Kazitskaya

Acta Biomedica Scientifica (Feb 2012)

DISTRIBUTION OF BIOCHEMICAL AND MOLECULAR-GENETIC MARKERS OF GENES IN WORKERS OF COAL MINING ENTERPRISES OF KUZBASS REGION SUFFERING FROM CHRONIC DUST BRONCHITIS

V. V. Zakharenkov,
N. I. Gafarov,
N. I. Panev,
A. N. Kucher,
M. B. Freydin,
A. A. Rudko,
T. K. Yadikina,
A. S. Kazitskaya

Affiliations

V. V. Zakharenkov: Scientific Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS, Novokuznetsk
N. I. Gafarov: Scientific Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS, Novokuznetsk
N. I. Panev: Scientific Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS, Novokuznetsk
A. N. Kucher: Scientific Research Institute of Medical Genetics of Tomsk Scientific Center SB RAMS
M. B. Freydin: Scientific Research Institute of Medical Genetics of Tomsk Scientific Center SB RAMS
A. A. Rudko: Scientific Research Institute of Medical Genetics of Tomsk Scientific Center SB RAMS
T. K. Yadikina: Scientific Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS, Novokuznetsk
A. S. Kazitskaya: Scientific Research Institute of Complex Problems of Hygiene and Occupational Diseases SB RAMS, Novokuznetsk

Journal volume & issue: Vol. 0, no. 1
pp. 93 – 97

Abstract

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Distribution of genotypes of biochemical markers of HP, GC, EsD, АсР genes, genotypes on polymorphic variants of the genes coding enzymes of biotransformation GSTT1 (GST-ɵ1) and GSTM1 (GST-μ1) and NOS3 (VNTR4 polymorphism) in the miners with chronic mechanic bronchitis, and in persons without this occupational pathology is investigated. It is shown that the owners of EsD 1-2, АсР bb genotypes are most subject to development of chronic mechanic bronchitis. Endogen factors of resistance to this disease are GC 1-1, EsD 1-1, АсР bc genotypes.

Published in Acta Biomedica Scientifica

ISSN: 2541-9420 (Print); 2587-9596 (Online)
Publisher: Scientific Сentre for Family Health and Human Reproduction Problems
Country of publisher: Russian Federation
LCC subjects: Science
Website: http://actabiomedica.ru/en/

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