The association of myeloperoxidase and SYNTAX score in patients with ST-elevation myocardial infarction

Abstract

Aims:There is evidence that myeloperoxidase (MPO) is a significant biomarker in various cardiovascular diseases. This work explored the relationship between MPO serum levels and SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery trial) score in patients with ST Elevation Myocardial Infarction (STEMI) after percutaneous coronary intervention.Methods:The study design was observational and cross-sectional with prospective patient enrollment. Patients were divided into two groups: those with a SYNTAX score >32 and those with a SYNTAX score ≤32. The SYNTAX score was calculated based on the SYNTAX 2.2 score calculator (syntaxscore.org). Patients were analyzed for demographic, and clinical characteristics, including body mass index, carbohydrate and lipid metabolic balance, troponin, and MPO levels. The MPO was measured by ELISA.Results:Ninety-three patients with STEMI were enrolled with a mean age of 63.77±8.55 years, and 50.5% were males. The MPO level had a significant positive correlation with the SYNTAX score in patients with SYNTAX score >32, r=0.58, p32 [odds ratio (OR): 1.055, 95% confidence interval (CI): 1.007- 1.101, p=0.009], also age (OR: 1.129, 95% CI: 1.031-1.401, p=0.007), high sensitivity of C-reactive protein (OR: 1.309, 95% CI: 1.167-2.878, p=0.030), and triglycerides (OR: 1.181, 95% CI: 1.077- 1.992, p=0.021) were significant predictors.Conclusions:The elevated MPO levels are related to a higher SYNTAX score and may help predict further STEMI development.

Keywords

• myeloperoxidase
• prognosis
• syntax score