Nature Communications (Apr 2020)

TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

  • Andrew J. Gunderson,
  • Tomoko Yamazaki,
  • Kayla McCarty,
  • Nathaniel Fox,
  • Michaela Phillips,
  • Alejandro Alice,
  • Tiffany Blair,
  • Mark Whiteford,
  • David O’Brien,
  • Rehan Ahmad,
  • Maria X. Kiely,
  • Amanda Hayman,
  • Todd Crocenzi,
  • Michael J. Gough,
  • Marka R. Crittenden,
  • Kristina H. Young

DOI
https://doi.org/10.1038/s41467-020-15404-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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TGFβ has a role in cancer immunosuppression but the exact mechanisms haven’t been fully elucidated. Here, using mouse models deficient in TGFβ-signaling, the authors show that loss of ALK5 in CD8 + T cells enhances their tumour trafficking and cytotoxicity suggesting that ALK5 inhibitors may have clinical utility.