Communications Biology (Feb 2022)
Ibrutinib reverses IL-6-induced osimertinib resistance through inhibition of Laminin α5/FAK signaling
- Li Li,
- Zhujun Li,
- Conghua Lu,
- Jianghua Li,
- Kejun Zhang,
- Caiyu Lin,
- Xiaolin Tang,
- Zhulin Liu,
- Yimin Zhang,
- Rui Han,
- Yubo Wang,
- Mingxia Feng,
- Yuan Zhuang,
- Chen Hu,
- Yong He
Affiliations
- Li Li
- Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University)
- Zhujun Li
- Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University)
- Conghua Lu
- Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University)
- Jianghua Li
- Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University)
- Kejun Zhang
- Department of Clinical Laboratory, Daping Hospital, Third Military Medical University (Army Medical University)
- Caiyu Lin
- Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University)
- Xiaolin Tang
- Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University)
- Zhulin Liu
- Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University)
- Yimin Zhang
- Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University)
- Rui Han
- Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University)
- Yubo Wang
- Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University)
- Mingxia Feng
- Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University)
- Yuan Zhuang
- National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University (Army Medical University)
- Chen Hu
- Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University)
- Yong He
- Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University)
- DOI
- https://doi.org/10.1038/s42003-022-03111-7
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 14
Abstract
The resistance mechanism of osimertinib, a third-generation EGFR-TKI, is mediated by IL-6 and Laminin α5/FAK signaling. Ibrutinib combined with osimertinib is presented as a strategy for overcoming osimertinib acquired resistance in EGFR mutant NSCLC.
