A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry

Julie C. Ullman; Jing Yang; Michael Sullivan; Jacob Bendor; Jonathan Levy; Ellen Pham; Katlin Silm; Helia Seifikar; Vikaas S. Sohal; Roger A. Nicoll; Robert H. Edwards

doi:10.1038/s41467-017-02716-5

Nature Communications (Jan 2018)

A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry

Julie C. Ullman,
Jing Yang,
Michael Sullivan,
Jacob Bendor,
Jonathan Levy,
Ellen Pham,
Katlin Silm,
Helia Seifikar,
Vikaas S. Sohal,
Roger A. Nicoll,
Robert H. Edwards

Affiliations

Julie C. Ullman: Departments of Neurology and Physiology, UCSF School of Medicine
Jing Yang: Departments of Neurology and Physiology, UCSF School of Medicine
Michael Sullivan: Departments of Neurology and Physiology, UCSF School of Medicine
Jacob Bendor: Departments of Neurology and Physiology, UCSF School of Medicine
Jonathan Levy: Kavli Institute for Fundamental Neuroscience, UCSF School of Medicine
Ellen Pham: Departments of Neurology and Physiology, UCSF School of Medicine
Katlin Silm: Departments of Neurology and Physiology, UCSF School of Medicine
Helia Seifikar: Kavli Institute for Fundamental Neuroscience, UCSF School of Medicine
Vikaas S. Sohal: Kavli Institute for Fundamental Neuroscience, UCSF School of Medicine
Roger A. Nicoll: Kavli Institute for Fundamental Neuroscience, UCSF School of Medicine
Robert H. Edwards: Departments of Neurology and Physiology, UCSF School of Medicine

DOI: https://doi.org/10.1038/s41467-017-02716-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 18

Abstract

Read online

The Na+/H+ exchanger NHE9 is proposed to regulate the H+ electrochemical gradient across endosomal membranes. Here, the authors find that NHE9 knockout mice show autism spectrum disorder-like behaviors and disrupted synaptic vesicle exocytosis due to impaired presynaptic calcium entry.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal